Human T-lymphotropic Virus Type I (HTLV-I) Proviral Load and Clinical Features in Iranian HAM/TSP Patients: Comparison of HTLV-I Proviral Load in HAM/TSP Patients
نویسندگان
چکیده
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective(s): HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the most common neurological manifestation of HTLV-I. The northeast of Iran is an endem-ic area for this virus. Host genetic and viral factors play important roles in developing HAM/TSP. The aim of this study was to evaluate the proviral load, and clinical features of HAM/TSP among Iranian to compare with other endemic parts of the world. Materials and Methods: In this systematic retrospective study, HTLV-I proviral load of 102 Iranian patients with HAM/TS,P and 34 healthy carriers in peripheral blood mononu-clear cells (PBMCs) were measured using real-time quantitative PCR assay. The diagnosis of HAM/TSP was made in accordance with the World Health Organization criteria.
منابع مشابه
Human T-lymphotropic Virus Type I (HTLV-I) Proviral Load and Clinical Features in Iranian HAM/TSP Patients
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